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Serum Cholesterol in Rats intoxicated with Carbon Tetrachloride

Nature volume 196, pages 1001–1002 (1962)Cite this article

Abstract

ORAL administration of carbon tetrachloride to rats causes an elevation in the amount of β-globulins while reducing the albumin, α1- and α2-globulins. Subsequent injury by subcutaneous sponge implantation, of the intoxicated rats augments both lt;α2- and β-regions1. Since the α2- and β-globulin regions of rat serum contain lipoproteins2, the fatty infiltration of the liver might be a responsible factor in some of the changes in electrophoretic patterns which are observed in injured, intoxicated rats. Carbon tetrachloride poisoning is apparently associated with a reduced rate of lipoprotein synthesis resulting in a. lowering of the plasma lipoprotein-level and an accumulation of liver lipids3. Preliminary experiments, however, showed no intensification of lipoprotein. staining (sudan black) of the paper electropherograms obtained with serum from injured, carbon tetrachloride intoxicated rats.

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Authors and Affiliations

  1. Departments of Physiological Chemistry and Anatomy, Detroit, 7, Michigan

    OTTO W. NEUHAUS, HECTOR F. BALEGNO & MARIETTA BIBEAU

Authors
  1. OTTO W. NEUHAUS
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  2. HECTOR F. BALEGNO
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  3. MARIETTA BIBEAU
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NEUHAUS, O., BALEGNO, H. & BIBEAU, M. Serum Cholesterol in Rats intoxicated with Carbon Tetrachloride. Nature 196, 1001–1002 (1962). https://doi.org/10.1038/1961001b0

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  • DOI: https://doi.org/10.1038/1961001b0

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