Abstract
IT has been reported previously from this laboratory1 that a high proportion of adult A-strain mice exposed to 500 r. whole-body irradiation followed by the injection (divided between the intra-peritoneal and intravenous routes) of 800 million–1,200 million (CBA × A)F1 hybrid spleen cells, become specifically tolerant of homografts of (CBA × A)F1 skin. On the other hand, four of five A-strain mice which received 500 r. whole-body irradiation and 700–800 million CBA spleen cells died after intervals ranging from 6 to 25 days with clinical and pathological signs of graft-versus-host disease, and the solitary survivor showed no tolerance to CBA skin.
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References
Michie, D., and Woodruff, M. F. A., Proc. Roy. Soc., B (in the press).
Russell, P. S., Ciba Found. Symp. on Transplantation, 1961(Churchill, London) (in the press).
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WOODRUFF, M. Prolonged Survival of Skin Homografts in Adult Mice following Sub-lethal Irradiation, Injection of Donor-Strain Spleen Cells and Administration of A-Methopterin. Nature 195, 727–728 (1962). https://doi.org/10.1038/195727a0
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DOI: https://doi.org/10.1038/195727a0
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