Abstract
BRACHMACHARI et al.1,2 have shown that certain metabolites like β-hydroxybutyrate, citrate, isocitrate and succinate, when injected into the animal (rabbit), produce hypoglycæmia, and this is interpreted as being due to a stimulus of the secretion of insulin. β-Hydroxybutyrate and citrate, according to the aforementioned experiments, seem to act, directly or indirectly, by different mechanisms, in view of the fact that the effect obtained is considerably more with citrate than with β-hydroxybutyrate and because this metabolite seems to increase first the content of active insulin/gm. of pancreas.
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References
Brachmachari, H. D., and Mahendra Kumar, Nature, 183, 51 (1959).
Brachmachari, H. D., and Raghupathy Sarma, G., Nature, 191, 491 (1961).
Candela, J. L. R-, Candela, R. R-, Martin-Hernandez, D., and Castilla-Cortazar, T., Proc. 4e Congrès I.D.F. Geneva, 629 (1961).
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R-CANDELA, J., R-CANDELA, R., MARTIN-HERNÁNDEZ, D. et al. β-Hydroxybutyrate and Sodium Citrate as Stimuli of the in vitro Secretion of Insulin. Nature 195, 711–712 (1962). https://doi.org/10.1038/195711a0
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DOI: https://doi.org/10.1038/195711a0
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