Abstract
α-D,L-Methylaspartic acid (MA) is a strong inhibitor of hepatic argininosuccinate synthetase; inhibition of this enzyme was first described by Braunstein et al.1, on the basis of in vitro experiments, in which 200 µmoles of MA were added to samples containing L-citrulline, L-aspartate, adenosine triphosphate (ATP) and a respiratory substrate, in presence of rat liver slices and homogenate.
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References
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CEDRANGOLO, F., DELLA PIETRA, G., CITTADINI, D. et al. Urea Synthesis in Rats treated with α-D,L-Methylaspartic Acid. Nature 195, 708–709 (1962). https://doi.org/10.1038/195708a0
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DOI: https://doi.org/10.1038/195708a0
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