Abstract
THE toxicity of bilirubin has been demonstrated in animals. It is known to inhibit brain respiration in vitro1, and to uncouple oxidative phosphorylation in isolated mitochondrias2. Its cytotoxic action on almost every cell in the animal has been recently emphasized by Rozdilsky3.
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References
Day, R. L., Proc. Soc. Exp. Biol. and Med., 85, 261 (1954).
Zetterstrom, R., and Ernster, L., Nature, 178, 1335 (1956).
Rozdilsky, B., Arch. Path., 72, 1, 8 (1961).
Cameron, G. R., Griffith, H., and Hasan, R., J. Path. Bact., 74, 327 (1957).
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SCHWARZMANN, V., COUINAUD, C. & BERTHAUX, N. Liver Enzymes in Biliary Retention. Nature 195, 706–707 (1962). https://doi.org/10.1038/195706a0
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DOI: https://doi.org/10.1038/195706a0
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