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Hæmophilia and the Protease Inhibitor in Peanuts

Nature volume 194, pages 980–981 (1962)Cite this article

Abstract

Boudreaux and Frampton's report1 on a hæmostatic factor in peanuts (Arachis hypogaea), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton1 considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts2. Verstraete et al.3 extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones.

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References

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Authors and Affiliations

  1. James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington, 15, D.C.

    TAGE ASTRUP, PIETER BRAKMAN & K.-E. SJØLIN

  2. Biological Institute, Carlsberg Foundation, Copenhagen

    TAGE ASTRUP, PIETER BRAKMAN & K.-E. SJØLIN

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  1. TAGE ASTRUP
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  2. PIETER BRAKMAN
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  3. K.-E. SJØLIN
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ASTRUP, T., BRAKMAN, P. & SJØLIN, KE. Hæmophilia and the Protease Inhibitor in Peanuts. Nature 194, 980–981 (1962). https://doi.org/10.1038/194980b0

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