Abstract
THE urine in patients with generalized melanoma contains substances which cause its dark colour when exposed to air—urinary melanogens1,2, of which there are two types3: (1) nitrogen melanogens, insoluble in ether or ethylacetate, giving a positive Thormählen test4–6—indole melanogens, as they are called, and (2) non-nitrogen melanogens, soluble in ether or ethylacetate, giving a negative Thormählen test—phenol melanogens.
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DUCHON, J. Tyrosine Metabolism in Melanoma. Nature 194, 976 (1962). https://doi.org/10.1038/194976a0
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DOI: https://doi.org/10.1038/194976a0
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