Abstract
THE discovery that cortisone acts as a teratogenic agent was made first in Fraser's laboratory at McGill1. In the intervening years, Fraser and his students have published a number of papers reporting investigations which have extended the original findings (for a general review see Fraser2). Within the framework of these experiments it appears that the effect of the cortisone on the mouse fœtus is specific. The only gross defect which has been reported so far is cleft palate (although some minor morphological effects have been recorded by Kalter3). The purpose of this communication is to report a new effect of cortisone on the developing mouse fœtus.
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References
Fraser, F. C., and Fainstat, T. D., Pediatrics, 8, 527 (1951).
Fraser, F. C., in Congenital Anomalies of the Face and Associated Structures, edit. by Pruzansky, S. (Thomas, Springfield, 1961).
Kalter, H., Ph.D., thesis, McGill University (1953).
Miller, J. R., Ph.D., thesis, McGill University (1958).
Runner, M. N., J. Nat. Cancer Inst., 15, 637 (1954).
Haskins, D., Anat. Rec., 108, 493 (1948).
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MILLER, J. Effect of Cortisone on the Developing Mouse Fœtus. Nature 194, 891–892 (1962). https://doi.org/10.1038/194891a0
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DOI: https://doi.org/10.1038/194891a0
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