Significance of Arachnoidal Cell Clusters in Man

Abstract

SINCE the early part of this century arachnoidal cell clusters in man have generally been accepted as a manifestation of advancing age. They were first described by Meyer¹ as a post-mortem finding in the meninges of patients suffering from mental disease. It has since become evident that they occurred not only in man but also in various laboratory animals^2,3. Their association with advancing age can be attributed largely to the work of Weed⁴, who, in a series of cats of different ages, reported that in very old animals the cell clusters were always present, while in very young animals they were never found.