Abstract
TASAKI et al.1,2 have demonstrated the existence of prolonged action potentials in the squid axon under tetraethylammonium and of a “hyperpolarizing response” of the normal squid axon in enriched potassium solutions. In a series of experiments they have evaluated the properties of the squid axon membrane in these two particular environments and were led to the conclusion that the Hodgkin–Huxley3 equations did not account for their observations, which had to be explained instead in terms of a “bistable state” hypothesis.
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References
Tasaki, I., and Hagiwara, S., J. Gen. Physiol., 40, 859 (1957).
Tasaki, I., J. Physiol., 148, 306 (1959).
Hodgkin, A. L., and Huxley, A. F., J. Physiol., 117, 500, 544 (1952).
George, E. P., and Johnson, E. A., Austral. J. Exp. Biol. and Med. Sci., 39, 385 (1961).
Fitzhugh, R., J. Gen. Physiol., 43, 867 (1960).
Spyropoulos, C. S., Amer. J. Physiol., 200, 203 (1961).
Huxley, A. F., Ann. N.Y. Acad. Sci., 81, 215 (1959).
Frankenhaeuser, B., and Hodgkin, A. L., J. Physiol., 137, 218 (1957).
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GEORGE, E., JOHNSON, E. Response of the Hodgkin–Huxley Model to Temperature and Chemical Impulses. Nature 194, 874–875 (1962). https://doi.org/10.1038/194874a0
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DOI: https://doi.org/10.1038/194874a0
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