Abstract
THE soluble polysaccharide (galactan)1 isolated from Mycoplasma mycoides var. mycoides (M. mycoides) can be used in precipitin or indirect hæmagglutination reactions to detect antibody to M. mycoides. When the galactan was used in place of the standard particulate antigen in the complement-fixation test for contagious bovine pleuropneumonia2 with known positive sera, fixation of complement was usually weak or absent. As unheated normal bovine serum has been shown to potentiate complement-fixation with heated bovine3,4 and swine5 antisera, its effect on complement-fixation by the galactan–bovine antibody system was tested.
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COTTEW, G. Enhancement of the Complement Fixation Reaction with a Soluble Antigen from Mycoplasma mycoides. Nature 194, 308 (1962). https://doi.org/10.1038/194308a0
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DOI: https://doi.org/10.1038/194308a0
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