Abstract
IT has been suggested that the membrane of the endoplasmic reticulum contained in the microsomal fraction is the site of the localization of tissue-specific antigens1. This structure may, however, be of immunologically complex nature, consisting of a number of antigenically different molecules, only several of which may be tissue-specific. This brief communication is concerned with attempts to identify and partially purify the tissue-specific antigens in the microsomal fraction of chicken kidney. In the immunological test the double diffusion agar technique was adopted, since this method is considered to be most adequate for the analysis of the complex antigen–antibody system and, in fact, it has been successfully used for the immunological characterization of the constituents of the different cell fractions of rat liver2.
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References
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OKADA, T. Tissue-Specificity in the Soluble Antigens in Kidney Microsomes. Nature 194, 306–307 (1962). https://doi.org/10.1038/194306a0
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DOI: https://doi.org/10.1038/194306a0
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