Abstract
RHEUMATOID factor is a macroglobulin component of the serum of patients with rheumatoid arthritis and can be demonstrated in a variety of serological tests by its reactivity with aggregated γ-globulin or with antibody combined with antigen. Exploiting its peculiar affinity for specifically bound antibody, I have used rheumatoid factor labelled with fluorescein in preliminary experiments as an immuno-histological reagent for locating sites of antibody fixation in sections of quick frozen tissue by Coons's technique.
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References
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Marshall, J. D., Eveland, W. C., and Smith, C. W., Proc. Soc. Exp. Biol. and Med., 98, 898 (1958).
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McCORMICK, J. Use of Fluorescein-labelled Rheumatoid Factor for locating Sites of Antibody Fixation in Tissues. Nature 194, 302–303 (1962). https://doi.org/10.1038/194302a0
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DOI: https://doi.org/10.1038/194302a0
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