Abstract
PHARMACOLOGICAL studies on the depression of spinal reflexes produced by the topical application of comparatively strong solutions of 3-hydroxytyramine to the exposed spinal cord have led to the conclusion that this catecholamine could be an inhibitory transmitter acting on spinal motoneurones1. Recently, it has also been suggested that derivatives of tryptamine may be transmitters within the spinal cord2. When applied electrophoretically, adrenaline and nor-adrenaline have no action on spinal neurones3 although these catecholamines, 3-hydroxytyramine and many derivatives of tryptamine depress the synaptic excitation of lateral geniculate neurones4. These agents are not, however, inhibitory transmitters in this portion of the visual pathway.
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McLennan, H., J. Physiol., 158, 411 (1961).
Vane, J. R., Collier, H. O. J., Corne, S. J., Marley, E., and Bradley, P. B., Nature, 191, 1068 (1961).
Curtis, D. R., Phillis, J. W., and Watkins, J. C., J. Physiol., 158, 296 (1961).
Curtis, D. R., and Davis, R., Nature, 192, 1083 (1961); Brit. J. Pharmacol. (in the press).
Curtis, D. R., Phillis, J. W., and Watkins, J. C., J. Physiol., 146, 185 (1959).
McGeer, E. G., McGeer, P. L., and McLennan, H., J. Neurochem., 8, 36 (1961).
Coombs, J. S., Eccles, J. C., and Fatt, P., J. Physiol., 130, 396 (1955). Curtis, D. R., ibid., 145, 175 (1959).
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CURTIS, D. Action of 3-Hydroxytyramine and some Tryptamine Derivatives on Spinal Neurones. Nature 194, 292 (1962). https://doi.org/10.1038/194292a0
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DOI: https://doi.org/10.1038/194292a0
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