Abstract
THE transplantability of virus-induced chicken leukæmia has never been clearly established. If intact cells are transferred to a homologous recipient bird, a leukæmia may develop. This has been interpreted as a transplanted leukæmia rather than the ordinary virus-induced disease mainly on the basis of an unusually rapid course1,2. The proof of the ability of leukæmic cells to grow in a homologous host rests, however, on the recognition of donor cells in the recipient. This communication describes the use of sex chromosomes as reliable markers for such a purpose. The technique takes advantage of the fact that male chicken cells contain two sex chromosomes of equal size, whereas the female cells contain only one (Fig. 1).
Similar content being viewed by others
Article PDF
References
Crank, F. P., and Furth, J., Proc. Soc. Exp. Biol. Med., 28, 987 (1931).
Lagerlöf, B., Acta Path. et Microbiol. Scand., 49, 438 (1960).
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A., Exp. Cell Res., 20, 613 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PONTÉN, J. Sex Chromosomes as Markers in Transplanted Chicken Leukæmic Cells. Nature 194, 97 (1962). https://doi.org/10.1038/194097a0
Issue Date:
DOI: https://doi.org/10.1038/194097a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.