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Interaction between Epithelial and Mesodermal Elements in Anthramine-induced Tumours of the Rat

Nature volume 194, pages 95–97 (1962)Cite this article

Abstract

IN a group of tumours arising in rat skin painted with 2-anthramine I have observed two examples of a compound tumour different in type from those described in previous similar experiments1–3. Their essential feature is that a sarcoma forms the stroma of an epithelial tumour. The natural history shows that the carcinoma and the sarcoma begin as separate growths and unite by collision. As a result the cytology and pattern of growth of the two elements are altered; the detail of the changes throws light on the relationship between epithelium and connective tissue, as well as on the process of carcinomatous invasion.

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Authors and Affiliations

  1. Institute of Dermatology, St. John's Hospital for Diseases of the Skin, London, W.C.2

    KENNETH V. SANDERSON

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  1. KENNETH V. SANDERSON
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SANDERSON, K. Interaction between Epithelial and Mesodermal Elements in Anthramine-induced Tumours of the Rat. Nature 194, 95–97 (1962). https://doi.org/10.1038/194095b0

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