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Visceral Pain evoked by Intra-Arterial Injection of Substance P

Nature volume 193, pages 983–984 (1962)Cite this article

Abstract

IT has been demonstrated1,2 that the intra-arterial injection of 1–2 µgm. of bradykinin into various organs throughout the body of the cat and dog will evoke vocalization and the other events which comprise the pseudo-affective reflexes which Woodworth and Sherrington3 obtained by electrical stimulation of somatic and splanchnic afferents in the decerebrate cat. The receptors concerned are the free-branching unmyelinated terminals of paravascular nerves which are found in the connective tissue space surrounding capillaries in the organs tested4.

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Authors and Affiliations

  1. Medical Sciences Research Laboratory, Miles Laboratories, Inc., Elkhart, Indiana

    G. D. POTTER, F. GUZMAN & R. K. S. LIM

Authors
  1. G. D. POTTER
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  2. F. GUZMAN
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  3. R. K. S. LIM
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POTTER, G., GUZMAN, F. & LIM, R. Visceral Pain evoked by Intra-Arterial Injection of Substance P. Nature 193, 983–984 (1962). https://doi.org/10.1038/193983a0

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