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Cholinergic Activity of Atropine

Nature volume 193, pages 1082–1083 (1962)Cite this article

Abstract

ATROPINE in suitable doses has been shown to potentiate the action of acetylcholine, and to possess anticholinesterase properties1,2. In addition, hyoscyamine is known to have cholinergic properties on the frog rectus muscle3. We have confirmed that atropine, in small doses, potentiates acetylcholine both in vivo, when the toxicity of acetylcholine is measured in mice, and in vitro, on the guinea pig ileum.

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References

  1. Lullmann, H., Forster, W., and Westermann, E., Arch. Exp. Path. und Pharmak., 215, 8 (1952). Lullmann, H., ibid., 216, 152 (1952).

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  2. Hazard, R., Savini, E., and Renier-Cornec, A., Arch. Intern. Pharmacodynamie, 120, 369 (1959).

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  3. Teitel, A., Nature, 190, 814 (1961).

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Authors and Affiliations

  1. Pharmacology Department, Crookes Laboratories, Ltd., Park Royal, London, N.W.10

    A. ASHFORD, G. B. PENN & JANET W. ROSS

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  1. A. ASHFORD
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  2. G. B. PENN
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  3. JANET W. ROSS
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ASHFORD, A., PENN, G. & ROSS, J. Cholinergic Activity of Atropine. Nature 193, 1082–1083 (1962). https://doi.org/10.1038/1931082b0

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