Abstract
THE structural1 and pharmacological2–6 similarity between glycyrrhetinic acid and adrenal corticoids has been reported. Glycyrrhetinic acid resembles the corticoids in mineralocorticoid2,3, anti-inflammatory4,5, anti-œstrogenic5 and anti-leukæmic6 activity. Since the glycoside, glycyrrhizin, has an inhibitory action on the pituitary-adrenal system7–9, it was of interest to ascertain whether the aglycone, glycyrrhetinic acid, exerted similar action.
Similar content being viewed by others
Article PDF
References
Beaton, J. H., and Spring, F. S., J. Chem. Soc., 3126 (1955).
Pelser, H. E., Willebrands, A. F., van der Heide, R. M., and Groen, J., Metab., Clin. and Exp., 2, 322 (1953).
Hassan, W., Palumbo, J. F., and Elmadjian, F. J., J. Amer. Pharm. Assoc., Sci. Ed., 43, 551 (1954).
Finney, R. S. H., and Somers G. F., J. Pharm. Pharmacol., 10, 613 (1958).
Kraus, S. D., J. Pharm. Pharmacol., 12, 300 (1960).
Logemann, W., Lauria, F., Cudkowicz, G., and Franceschino, J., Nature, 187, 607 (1960).
Kraus, S. D., J. Exp. Med., 106, 415 (1957).
Kraus, S. D., J. Exp. Med., 108, 325 (1958).
Carpetti, G., and Magnani, B., Gior. clin. med., 34, 649 (1953).
Bessey, O. A., J. Biol. Chem., 126, 771 (1938).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KRAUS, S. Beta-Glycyrrhetinic Acid on the Adrenal Ascorbic Acid of Unstressed and Stressed Immature Female Rats. Nature 193, 1082 (1962). https://doi.org/10.1038/1931082a0
Issue Date:
DOI: https://doi.org/10.1038/1931082a0
This article is cited by
-
Licorice (review)
Pharmaceutical Chemistry Journal (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.