Abstract
IT has recently been reported that a water-soluble protein extracted from brain tissue has encephalitogenic activity1. The method of extraction of this water-soluble protein is very similar to that used by Dounce and Monty for the extraction of histones from rat liver nuclei2. Lederer3 has reported that killed cells of the H 37 RV strain of Mycobacterium tuberculosis can produce allergic encephalomyelitis in rabbits. A basic protein from this same strain has been shown to induce a positive tuberculin reaction4. To determine whether a synthetic basic polypeptide might influence the production of experimental allergic encephalomyelitis we examined the effect of polylysine on this experimental disease in rabbits.
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KORNGUTH, S., BENNETT, D., THOMPSON, H. et al. Encephalitogenic Activity of Poly-L-lysine. Nature 193, 1081 (1962). https://doi.org/10.1038/1931081a0
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DOI: https://doi.org/10.1038/1931081a0
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