Abstract
THE cyclic nucleotide, adenosine-3′,5′-phosphate (3′,5′-AMP), found in animal tissues1,2, has been shown to increase in concentration in slices from the adrenal cortex of the ox when these are incubated in the presence of corticotrophin (ACTH)3. Sectioned rat adrenal glands respond to ACTH in vitro with an increased output of corticosteroid4–7, and addition of 3′,5′-AMP elicits a response in corticosteroid production under these conditions equal to or greater than that produced by ACTH8.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rall, T. W., and Sutherland, E. W., J. Biol. Chem., 232, 1065 (1958).
Sutherland, E. W., and Rall, T. W., J. Biol. Chem., 232, 1077 (1958).
Haynes, jun., R. C., J. Biol. Chem., 233, 1220 (1958).
Saffran, M., and Bayliss, M. J., Endocrinol., 52, 140 (1953).
Birmingham, M. K., Elliott, F. H., and Valere, P., Endocrinol., 53, 687 (1953).
Schonbaum, E., Birmingham, M. K., and Saffran, M., Canad. J. Biochem. and Physiol., 34, 527 (1956).
Peron, F. G., and Koritz, S. B., J. Biol. Chem., 233, 256 (1958).
Haynes, jun., R. C., Koritz, S. B., and Peron, F. G., J. Biol. Chem., 234, 1421 (1959).
Symington, T., Biochem. Soc. Symp., 18, 40 (1960).
Grant, J. K., and Griffiths, K., Glasgow Conf. Human Adrenal Cortex, 26 (E. and S. Livingston, Ltd., Edinburgh, 1962).
Stadie, W. C., and Riggs, B. C., J. Biol. Chem., 154, 687 (1944).
Umbreit, W. W., Burris, R. H., and Stanffer, J. F., Manometric Techniques, 149 (Burgess Publishing Co., Minneapolis, 1957).
Dixon, H. B. F., and Stack-Dunne, M. P., Biochem. J., 61, 483 (1955).
Sayers, M. A., Sayers, G., and Woodbury, L. A., Endocrinol., 42, 379 (1948).
Allen, W. M., J. Clin. Endocrinol., 10, 71 (1950).
Elliott, F. M., and Schally, A. V., Canad. J. Biochem. and Physiol., 33, 174 (1955).
Saffran, M., Grad, B., and Bayliss, M. J., Endocrinol., 50, 639 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STUDZINSKI, G., GRANT, J. Effect of Adenosine-3′,5′-phosphate on Corticosteroid Production in vitro by Slices of the Adrenal Cortex of Human Beings. Nature 193, 1075–1076 (1962). https://doi.org/10.1038/1931075a0
Issue Date:
DOI: https://doi.org/10.1038/1931075a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.