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Acquired Tolerance to Homografts produced by Homologous Spleen Cell Injection in Adult Mice

Nature volume 192, pages 564–565 (1961)Cite this article

Abstract

THE dosage of skin homografts has been shown to be a factor in their survival. While small homografts show a prolonged survival-time when compared with medium-sized grafts, the application of large or near total body size homografts results in increased survival time1,2. Billingham and Sparrow also showed that intravenous injection of living homologous dissociated epidermal cells caused a two- to three-fold increase in the survival of skin homografts which were afterwards placed on rabbit hosts3. Because of our success in producing acquired tolerance to outcross skin in adult mice using parent–F1 hybrid parabiosis4,5, the following experiment was designed to study the effects of dosage of homologous antigen on the future recipients of skin homografts in adults, reasoning along lines that the success of parabiosis was primarily a dosage phenomenon.

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References

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Authors and Affiliations

  1. Department of Surgery, University of Minnesota Medical School, Minneapolis, 14, Minnesota

    RONALD D. GUTTMANN & J. BRADLEY AUST

Authors
  1. RONALD D. GUTTMANN
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  2. J. BRADLEY AUST
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GUTTMANN, R., AUST, J. Acquired Tolerance to Homografts produced by Homologous Spleen Cell Injection in Adult Mice. Nature 192, 564–565 (1961). https://doi.org/10.1038/192564a0

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