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Determination of Argininosuccinic Acid by Ion-Exchange Chromatography

Nature volume 192, pages 555–556 (1961)Cite this article

Abstract

RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children1 was identified as argininosuccinic acid (ASA)2. This is unstable in weakly acid aqueous solutions and cyclizes3. More recently Westall4 has shown that under these conditions two separate types of anhydride (B and C) are formed, rapidly at high but more slowly at room temperatures.

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References

  1. Allan, J. D., Cusworth, D. C., Dent, C. E., and Wilson, V. K., Lancet, i, 182 (1958).

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Authors and Affiliations

  1. Medical Unit, University College Hospital Medical School, University Street, London, W.C.1

    D. C. CUSWORTH & R. G. WESTALL

Authors
  1. D. C. CUSWORTH
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  2. R. G. WESTALL
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CUSWORTH, D., WESTALL, R. Determination of Argininosuccinic Acid by Ion-Exchange Chromatography. Nature 192, 555–556 (1961). https://doi.org/10.1038/192555a0

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