Abstract
HAGEMAN factor is a clot-producing substance which is not found in the plasma of patients with Hageman trait1. The coagulation of blood obtained from patients with Hageman trait is grossly abnormal, although hæmostasis is usually unimpaired. The defect in blood in Hageman trait may be corrected in vitro by the addition of partially purified Hageman factor1,2. Margolis3,4 has shown that Hageman factor is required for the appearance in glass-treated human plasma of a permeability factor and of a pain-producing and smooth muscle-contracting substance believed to be a plasma kinin. Three separate stages have been proposed for the release of plasma kinin when plasma was treated with glass.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ratnoff, O. D., and Colopy, J. E., J. Clin. Invest., 34, 602 (1955).
Ratnoff, O. D., Hageman Trait, Thrombosis et Diath. Hæmor., 4, Supp. 116 (1960).
Margolis, J., Austral. J. Exp. Biol., 37, 239 (1959).
Margolis, J., J. Physiol., 151, 238 (1960).
Webster, M. E., and Pierce, J. V., J. Pharm. Exp. Therap., 130, 484 (1960).
Werle, E., Polypeptides which Stimulate Plain Muscle, edit. by Gaddum (E. and S. Livingstone, 1955).
Werle, E., Forell, M. M., and Maier, L., Arch. Exp. Path. Pharmakol., 225, 369 (1955).
Waaler, B. A., Scand. J. Clin. Lab. Invest., 11, Supp. 37 (1959).
Ratnoff, O. D., Davie, E. W., and Mallett, D. L., J. Clin. Invest., 40, 803 (1961).
Ratnoff, O. D., Hartmann, R. C., and Conley, C. L., J. Exp. Med., 91, 123 (1950).
Keele, C. A., in Polypeptides which affect Smooth Muscles and Blood Vessels, edit. by Schachter (Pergamon Press, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WEBSTER, M., RATNOFF, O. Role of Hageman Factor in the Activation of Vasodilator Activity in Human Plasma. Nature 192, 180–181 (1961). https://doi.org/10.1038/192180a0
Issue Date:
DOI: https://doi.org/10.1038/192180a0
This article is cited by
-
The role of kallikrein in leukocyte migration inhibition
Inflammation (1979)
-
Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema
Archives of Dermatological Research (1978)
-
On the endogenous mechanism of kinin release
Naunyn-Schmiedebergs Archiv f�r Pharmakologie (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
