Abstract
WHILE studying the guinea pig mast cell1, we have discovered a new chemical family of histological fixatives, namely, the glycol ethers. These alcohol derivatives, possessing both an ether and an alcohol group, are miscible with most liquids and are excellent solvents for a variety of substances completely insoluble in water. Marketed under the trade names of ‘Cellosolves’ and ‘Carbitals’, they have found wide use as solvents for cellulose esters in the lacquer industry. Conversely, they do coagulate and precipitate proteins as well as mucopolysaccharides.
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References
Shelley, W. B., and Florence, R., A Technique for the Study of Mast Cells : The Guinea Pig Mesentery (in the press).
Gray, P., The Microtomist's Formulary and Guide (Blakiston Co., New York, 1954).
Baker, J. R., Principles of Biological Microtechnique (John Wiley and Sons, Inc., 1958).
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SHELLEY, W., FLORENCE, R. Ethylene Glycol Monomethyl Ether, a New Fixative for Histological Work. Nature 191, 719–720 (1961). https://doi.org/10.1038/191719a0
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DOI: https://doi.org/10.1038/191719a0
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