Abstract
LEVVY1 showed that D-glucosaccharo-1,4-lactone was a very powerful inhibitor for β-glucuronidase. Recently, Boyland et al.2 suggested that the oral administration of D-glucosaccharo-1,4-lactone should be effective in the prevention of bladder cancer. It is probable that D-glucosaccharo-1,4-lactone, when administered per os, would, even though the lactone ring may partly be opened, yet more or less inhibit the tissue β-glucuronidase. In that event, as a result of inhibition of hydrolytic action of the enzyme, excretion of glucuronide compounds in urine would be increased. The present work has shown that the orally administered D-glucosaccharo-1,4-lactone actually caused an inhibition of liver β-glucuronidase.
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References
Levvy, G. A., Biochem. J., 52, 464 (1952).
Boyland, E., Wallace, D. M., and Williams, D. C., Brit. J. Cancer, 11, 578 (1957).
Karunairatnam, M. C., and Levvy, G. A., Biochem. J., 44, 599 (1949).
Fishman, W. H., Methods in Enzymology, 1, 263 (Academic Press Inc., 1955).
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AKAMATSU, S., KIYOMOTO, A., HARIGAYA, S. et al. Inhibition of β-Glucuronidase by Oral Administration of D-Glucosaccharo-1,4-Lactone. Nature 191, 1298–1299 (1961). https://doi.org/10.1038/1911298a0
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DOI: https://doi.org/10.1038/1911298a0
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