Abstract
SINCE the early works on the soluble fractions of collagen were published, two fundamental theories have been put forward claiming that probable precursors might be found either in the neutral salt-soluble collagen or in the acid-soluble collagen. At present Jackson1, and Gross2, seem to have modified the earlier approach on the ground that the various solutions used for extraction differ only in their capacity to split the cross-linkings between the fibre chains. This points to the conclusion that the earliest precursors are to be found in the solutions of the weakest ionic strength that still keep their extraction capacity.
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References
Jackson, D. S., and Bentley, J. P., J. Biophys. Biochem. Cytol., 7, 37 (1960).
Gross, J., Connective Tissue, Thrombosis and Arteriosclerosis (Acad. Press, New York and London, 1959).
Jackson, D. S., Biochem. J., 65, 277 (1957).
Green, N. M., and Lowther, D. A., Biochem. J., 71, 55 (1959).
Gould, B. S., and Woessner, J. F., J. Biol. Chem., 226, 289 (1957).
Neumann, R. E., and Logan, M. A., J. Biol. Chem., 186, 549 (1950).
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CADAVID, N., DENDUCHIS, B. & MANCINI, R. Collagen Fractions in the Skin of New-Born and Adult Rats. Nature 191, 1297–1298 (1961). https://doi.org/10.1038/1911297a0
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DOI: https://doi.org/10.1038/1911297a0
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