Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Immunological Observations in Experimental Silicosis

Abstract

EVIDENCE which suggests that an immunological mechanism may participate in the pathogenesis of human silicosis has been summarized by Vigliani and Pernis1. We have attempted to identify such a mechanism in the experimental disease by applying the fluorescent antibody technique of Coons and Kaplan to rats with silicosis at different stages of development, while observing at the same time the γ-globulin- and conglutinin-levels in their sera.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Vigliani, E. C., and Pernis, B., J. Occup. Med., 1, 319 (1959).

    Google Scholar 

  2. Coombs, A. M., and Coombs, R. R. A., J. Hyg., 51, 509 (1953).

    Article  CAS  Google Scholar 

  3. Nichol, J. C., and Deutsch, H. F., J. Amer. Chem. Soc., 70, 80 (1948).

    Article  CAS  Google Scholar 

  4. Chadwick, C. S., McEntegart, M. G., and Nairn, R. C., Lancet, i, 412 (1958).

  5. Ceppellini, R., and Pernis, B., Nature, 181, 55 (1958).

    Article  ADS  CAS  Google Scholar 

  6. Grabar, P., and Williams, jun., C. A., Biophys. Biochim. Acta, 17, 67 (1955).

    Article  CAS  Google Scholar 

  7. Vazquez, J. J., and Dixon, F. J., Lab. Invest, 6, 205 (1957).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JONES, J., HEPPLESTON, A. Immunological Observations in Experimental Silicosis. Nature 191, 1212–1213 (1961). https://doi.org/10.1038/1911212b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1911212b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing