Abstract
EVIDENCE which suggests that an immunological mechanism may participate in the pathogenesis of human silicosis has been summarized by Vigliani and Pernis1. We have attempted to identify such a mechanism in the experimental disease by applying the fluorescent antibody technique of Coons and Kaplan to rats with silicosis at different stages of development, while observing at the same time the γ-globulin- and conglutinin-levels in their sera.
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References
Vigliani, E. C., and Pernis, B., J. Occup. Med., 1, 319 (1959).
Coombs, A. M., and Coombs, R. R. A., J. Hyg., 51, 509 (1953).
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JONES, J., HEPPLESTON, A. Immunological Observations in Experimental Silicosis. Nature 191, 1212–1213 (1961). https://doi.org/10.1038/1911212b0
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DOI: https://doi.org/10.1038/1911212b0
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