Abstract
GENETIC research of the past ten years has shown that the classical gene can be subdivided by mutation, recombination and function. The region of a chromosome which determines the production of one enzyme can be inactivated by mutation at many independent sites which are separable by recombination. One well-known example is the rII region of phage T4 (ref. 1. For other genes analysed in micro-organisms see Pontecorvo2 and Demerec and Hartman3).
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References
Benzer, S., Proc. U.S. Nat. Acad. Sci., 47, 403 (1961).
Pontecorvo, G., Trends in Genetic Analysis (New York, 1958).
Demerec, M., and Hartman, P. E., Ann. Rev. Microbiol., 13, 377 (1959).
Leupold, U., a, Schweiz. Z. allg. Path. Bakt., 20, 535 (1957); b, Cold Spring Harbor Symp. Quant. Biol., 23, 161 (1958); c, Arch. Julius-Klaus-Stiftung Zürich (in preparation).
Schuster, H., Gierer, A., and Mundry, K. W., Abh. Deutsch. Akad. Wiss., Berlin, 76 (1960).
Vielmetter, W., and Schuster, H., Z. Naturforsch., 15, b, 304 (1960).
Kaudewitz, F., Abh. Deutsch. Akad. Wiss., Berlin, 86 (1960).
Schuster, H., Z. Naturforsch., 15, b, 298 (1960).
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GUTZ, H. Distribution of X-ray- and Nitrous Acid-induced Mutations in the Genetic Fine Structure of the ad7 Locus of Schizo-saccharomyces pombe. Nature 191, 1125–1126 (1961). https://doi.org/10.1038/1911125b0
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DOI: https://doi.org/10.1038/1911125b0
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