Abstract
IN 1932 it was observed by Geoffrey Keynes1, working on the disappearance of human mammary carcinoma by surrounding the growth with radium needles, that on cutting out a piece of the tumour after the needles had been in place for ten days, some of the malignant cells were alive and became grafted in the overlying biopsy skin-incision, although the rest of the tumour from which the piece had been removed eventually disappeared. This suggests that the surrounding normal cells might have been acted on by the radiations so as to continue to pour out a chemical substance which led to the death of the cancer cells2.
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References
Keynes, Geoffrey, Brit. J. Surg., 19 415 (1932).
Pannett, C. A., Lancet, 829–830 (April 20, 1957).
Kuzin, A. M., Radiobiology Symposium, Moscow, Oct. 18–20, 1960, reported in The New Scientist, p. 1200 (Nov. 3, 1960).
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COMPTON, A., PANNETT, C. Effect of Irradiated Normal Tissues on the Growth of Mouse Carcinoma. Nature 191, 1101–1102 (1961). https://doi.org/10.1038/1911101a0
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DOI: https://doi.org/10.1038/1911101a0
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