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Catalysis of Incorporation of 14C-Uridine into Rat Lens Ribonucleic Acid by Rat Lens Enzyme System

Abstract

MAMMALIAN lenses may now be considered to be centres of the active metabolism of protein on the basis of the recent findings of Devi, Lerman and Sarkar1 on the existence in rat lens of a very active system which catalyses the incorporation of amino-acids into lens ribonucleic acid (RNA) and proteins, and on the basis of the occurrence of many proteases in rat lens as demonstrated by Zeller and Devi2 and Devi3,4. The relatively high concentration of RNA in rat lens as reported by Dische and Devi5 and its key role in protein synthesis as shown by various investigators6,7 has stimulated us to examine whether or not there also exists in rat lens any system capable of synthesizing RNA.

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References

  1. Devi, Anima, Lerman, Sidney, and Sarkar, Nirmal, Nature, 190, 1193 (1961).

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  2. Zeller, E. A., and Devi, Anima, Amer. J. Ophthal., 44, Part 2, 281 (1957).

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DEVI, A., SARKAR, N. Catalysis of Incorporation of 14C-Uridine into Rat Lens Ribonucleic Acid by Rat Lens Enzyme System. Nature 191, 1094–1095 (1961). https://doi.org/10.1038/1911094a0

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