Abstract
IN a previous communication1, evidence was presented that an enzyme system, isolated from pig heart, catalysed the oxidation of acetate to succinate. Aconitase, assayed by the method of Racker2, was not detectable and the addition of malate to the incubation mixture did not increase the incorporation of acetate into succinate. Consequently, the formation of succinate was attributed to a Thunberg condensation and the slow rate (7 mμmoles/br./mgm. protein) was explained by the unfavourable equilibrium3.
Similar content being viewed by others
Article PDF
References
Davies, D. D., Nature, 181, 339 (1958).
Racker, E., Biochim. Biophys. Acta, 4, 211 (1950).
Seaman, G. R., J. Biol. Chem., 228, 149 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIES, D. Synthesis of Succinate from Acetate. Nature 191, 1093 (1961). https://doi.org/10.1038/1911093a0
Issue Date:
DOI: https://doi.org/10.1038/1911093a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.