Abstract
CROWN gall tumours in plants are initiated by the action of virulent strains of Agrobacterium tumefaciens (Smith and Town) Conn on susceptible plant cells. Once these cells have been altered to tumour cells, the presence of the bacteria is no longer required for their continuing, autonomous growth1. The unknown agent or method by which this alteration of properly conditioned cells to tumour cells is accomplished is not known2. There have been a number of recent claims that this agent is a nucleic acid, specifically a deoxyribonucleic acid (DNA)3,4 or that DNA plays some accessory part in tumour induction5. Some of these claims have been subject to critical examination and have been shown to rest on inadequate evidence6.
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LIPETZ, J., STONIER, T. Effect of 5-Bromuracil on Crown Gall Tumour Induction. Nature 190, 929–930 (1961). https://doi.org/10.1038/190929a0
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DOI: https://doi.org/10.1038/190929a0
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