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Isolation of Peptides containing Hydroxyproline from Animal Tissues

Nature volume 190, pages 909–910 (1961)Cite this article

Abstract

THE idea that fibrogenic cells secrete peptide which, in extracellular spaces, is built into collagen fibre has been postulated repeatedly in the course of the past thirty years1,2. There is no direct evidence, so far, of the existence of a peptide which, as a precursor of collagen, should contain the typical collagen imino-acid hydroxyproline. Peptides containing hydroxy-proline isolated from urine3,4 can be considered rather as products of collagen catabolism than as steps in the course of biosynthesis of collagen.

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Authors and Affiliations

  1. Institute of Industrial Hygiene and Occupational Diseases, Karlovo nám. 33, Praha, 2, Czechoslovakia

    V. KOBRLE & M. CHVAPIL

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  1. V. KOBRLE
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  2. M. CHVAPIL
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KOBRLE, V., CHVAPIL, M. Isolation of Peptides containing Hydroxyproline from Animal Tissues. Nature 190, 909–910 (1961). https://doi.org/10.1038/190909a0

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