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Renal Proliferation in the Unilaterally Nephrectomized Rat

Nature volume 190, pages 175–176 (1961)Cite this article

Abstract

RENAL growth following unilateral nephrectomy has been referred to as ‘compensatory renal hypertrophy’1. The work of Rollason emphasizes the importance of hyperplasia in this process2. Utilizing thymidine as a specific precursor of deoxyribomicleic acid (DNA), and assuming the constancy of DNA in the absence of dividing cells, the incorporation of thymidine serves as an index of cellular proliferation3. We now describe the effect of uninephrectomy on the incorporation of tritium-labelled thymidine into renal DNA.

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Authors and Affiliations

  1. Mary Imogene Bassett Hospital (affiliated with Columbia University), Cooperstown, New York

    DAVID M. KESSNER & E. DONNALL THOMAS

Authors
  1. DAVID M. KESSNER
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  2. E. DONNALL THOMAS
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KESSNER, D., DONNALL THOMAS, E. Renal Proliferation in the Unilaterally Nephrectomized Rat. Nature 190, 175–176 (1961). https://doi.org/10.1038/190175b0

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