Abstract
NUCLEOPROTEINS seem to be effective antigens1, and anti-nucleoprotein sera produced in rabbits exhibit a definite cytotoxic activity on the cells of different lines grown in tissue culture2. On the other hand, it is generally believed that ribonucleic acid and ribonucleoprotein are instrumental in protein synthesis, and that these cell constituents provide also the patterns for de novo production of highly specific proteins, such as immune antibodies. It may be deduced, therefore, that the capacity of antibody-protein formation can be affected by the action of an anti-nucleoprotein serum. The present experiment was done in order to investigate the immunological events which are associated with the activity of anti-ribonucleoprotein and anti-deoxyribonucleoprotein sera.
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JANKOVIČ, B., ISAKOVIČ, K. & HORVAT, J. Partial Inhibition of Antibody Formation by means of Anti-Ribonucleoprotein Serum. Nature 190, 1218–1219 (1961). https://doi.org/10.1038/1901218a0
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DOI: https://doi.org/10.1038/1901218a0
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