Abstract
MEASUREMENT by Puck and Marcus of the reproductive survival of randomly dividing cultures of HeLa S3 cells after X-irradiation revealed an exponential response to dose following a shoulder1. However, the possibility was not excluded that these populations are in fact heterogeneous, the cells undergoing small, or large but brief, fluctuations in sensitivity during the division cycle. We have examined this possibility by irradiating synchronously growing populations at various times after mitosis.
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References
Puck, T. T., and Marcus, P. I., J. Exp. Med., 103, 653 (1956).
Marcus, P. I., Virology, 9, 546 (1959).
Horn, R., and Puck, T., Methods in Enzymology (in the press).
Marcus, P. I., and Puck, T. T., Virology, 6, 405 (1958).
Painter, R. B., and Drew, R. M., Lab. Invest., 8, 278 (1959).
Puck, T. T., Proc. U.S. Nat. Acad. Sci., 44, 772 (1958).
Lea, D. E., Actions of Radiations on Living Cells, second ed., 224 (Cambridge Univ. Press, 1956).
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TERASIMA, T., TOLMACH, L. Changes in X-ray Sensitivity of HeLa Cells during the Division Cycle. Nature 190, 1210–1211 (1961). https://doi.org/10.1038/1901210a0
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DOI: https://doi.org/10.1038/1901210a0
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