Abstract
THE enhancing (or XYZ) effect on the growth of tumour homografts in animals pre-treated with non-living donor tissue first described by Flexner and Jobling1 led to many fruitful immunogenetic investigations in oncology. In order to explain the phenomenon, several working hypotheses have been evolved: the ‘blockage’ hypothesis was advocated by Medawar and co-workers2 and Snell3, ‘immunoselection’ by Hauschka and co-workers4 and the hypothesis of some ‘physiological’ alteration in the tumour cells was argued by Kaliss5. According to experiments of Casey and co-workers6, it is possible to enhance the tumour growth in the strain from which the tumour originated. It is difficult to explain these results on the hypotheses mentioned above.
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Billingham, R. E., Brent, L., and Medawar, P. B., Transpl. Bull., 3, 84 (1956). Medawar, P. B., Proc. Roy. Soc., B, 146, 1 (1956).
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Hauschka, T. S., Kvedar, B. J., and Grinell, S. T., Ann. N.Y. Acad. Sci., 63, 683 (1956).
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Casey, A. E., Ross, G. L., and Langston, R., Proc. Soc. Exp. Biol. Med., 72, 83 (1949). Casey, A. E., Laster, jun., W. R., and Ross, G. L., Proc. Soc. Exp. Biol. Med., 77, 358 (1951). Casey, A. E., and Gunn, J., Proc. Soc. Exp. Biol. Med., 80, 610 (1952).
Kaliss, N., Cancer Res., 18, 992 (1958). Allegretti, N., Bull. Sci. Zagreb, 5, 109 (1960).
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ALLEGRETTI, N. Growth of Tumours in Rats fed with 4-Dimethylaminoazobenzene injected with Homogenized Tumour mixed with Freund Adjuvant. Nature 190, 1207 (1961). https://doi.org/10.1038/1901207a0
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DOI: https://doi.org/10.1038/1901207a0
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