Abstract
Milch, Rall and Tobie1,2 observed the property of antibiotics of the tetracycline series of becoming localized specifically in bony tissue formed during the administration of these drugs, and persisting in the zone of localization until the structural remodelling has caused the absorption of the bony areas which have bound the tetracyclines. This observation seemed likely to offer a practical and useful method of vital staining, especially for the detection of the turnover of bone.
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References
Milch, I. C., Rall, D. P., and Tobie, J. E., J. Nat. Cancer Inst., 19, 87 (1957).
Milch, I. C., Rall, D. P., and Tobie, J. E., J. Bone and Joint Surg., 40, A, 897 (1958).
Regna, P. P., and Solomons, I. A., Ann. N.Y. Acad. Sci., 53, 229 (1950).
Sognnaes, R. F., Shaw, J. H., Solomon, A. K., and Harvold, E., Anat. Rec., 104, 319 (1949).
Pitzurra, M., Bruni, M., and Muzii, E., Annali d'Igiene Sclavo, 2, 213 (1960).
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MUZII, E. Detection by Fluorescence of Oxytetracycline bound to Bone. Nature 189, 934–935 (1961). https://doi.org/10.1038/189934a0
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DOI: https://doi.org/10.1038/189934a0
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