Abstract
A NUMBER of exogenous substances such as penicillin, ‘Diodrast’ and p-aminohippuric acid (PAH) are secreted in the proximal tubules. Nothing definitely is known about the mechanism of uptake of these substances in the tubular cells and further transport into the tubular lumen1. It is likely that enzymatic reactions are involved so that PAH reacts with an enzyme (carrier) in the cell membrane since the kidney cells seem to be impermeable to it. The concentration of PAH therefore approaches zero in the vicinity of the cell. However, it must traverse the wall of the capillary and the interstitial water before reaching the tubular cell. This probably takes place as diffusion along a concentration gradient. The concentration of PAH in the capillary plasma will therefore never be zero.
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References
Foulkes, E. C., and Miller, B. F., Amer. J. Physiol., 196, 86 (1959).
Kinter, W. B., and Pappenheimer, J. R., Amer. J. Physiol., 185, 391 (1956).
Harth, O., Kreienberg, W., and Lutz, J., Pflügers Arch., 270, 174 (1959).
Baldwin, E., Dynamic Aspects of Biochemistry (Cambridge Univ. Press, 1957).
Maxwell et al. (cited in ref. 6).
Smith, H., The Kidney: Structure and Function in Health and Disease (Oxford Univ. Press, New York, 1951).
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KIIL, F. Dynamics of Renal Proximal Tubular Secretion. Nature 189, 927–928 (1961). https://doi.org/10.1038/189927a0
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DOI: https://doi.org/10.1038/189927a0
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