Abstract
IN a previous communication1 we reported the results of a study of the hæmoglobin of 26 human fœtuses and reviewed the relevant literature. In 25 fœtuses from pregnancies of 10 weeks or more we were unable to find a major hœmoglobin component which differed from fœtal hæmoglobin (Hb–F) or adult hæmoglobin (HbæA). In a 9-week fœtus of 3.5 cm. crown–rump length, however, the largest hæmoglobin component was found to differ from Hb–F and Hb–A; its rate of alkali denaturation was intermediate, as also was its electrophoretic mobility in agar at pH 6.2, and it was assumed to be the ‘embryonic’ hæmoglobin of Drescher and Künzer2. The present communication describes the finding of two new hæmoglobin variants in a human fœtus of only 3.4 cm. crown–rump length from a 10½-week pregnancy. For convenience these will be referred to as hæmoglobins Gower 1 and Gower 2.
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References
Butler, E. A., Flynn, F. V., and Huehns, E. R., Clin. chim. Acta, 5, 571 (1960).
Drescher, H., and Künzer, W., Klin. Wschr., 32, 92 (1954).
Singer, K., Chernoff, A. I., and Singer, L., Blood, 6, 413 (1951).
Künzer, W., Zbl. ges. Kinderheilk., 73, 265 (1953).
Robinson, A. R., Robson, M., Harrison, A. P., and Zuelzer, W. W., J. Lab. Clin. Med., 50, 745 (1957).
Poulik, M. D., Nature, 180, 1477 (1957).
Raper, A. B., Gammack, D. B., Huehns, E. R., and Shooter, E. M., Brit. Med. J., ii, 1257 (1960).
Gratzer, W. B., and Beaven, G. H., Clin. chim. Acta, 5, 577 (1960).
Beaven, G. H., Ellis, M. J., and White, J. C., Brit. J. Hæmat., 6, 1 (1960).
Fessas, Ph., and Papaspyrou, A., Science, 126, 1119 (1957).
Ager, J. A. M., and Lehmann, H., Brit. Med. J., i, 929 (1958).
Raper, A. B., Ager, J. A. M., and Lehmann, H., Brit. Med. J., i, 1537 (1960).
Fessas, Ph., Mastrokalos, N., Fostiropoulos, G., Vella, F., Ager, J. A. M., and Lehmann, H., Nature, 183, 30 (1959).
Allen, D. W., Schroeder, W. A., and Balog, J., J. Amer. Chem. Soc., 80, 1628 (1958).
Huisman, T. H. J., and Meyering, C. A., Clin. chim. Acta, 5, 103 (1960).
Matsuda, G., Schroeder, W. A., Jones, R. T., and Weliky, N., Blood, 16, 984 (1960).
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HUEHNS, E., FLYNN, F., BUTLER, E. et al. Two New Hæmoglobin Variants in a Very Young Human Embryo. Nature 189, 496–497 (1961). https://doi.org/10.1038/189496a0
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DOI: https://doi.org/10.1038/189496a0
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