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Antiaccelerator Action of Methoxamine

Nature volume 189, pages 493–494 (1961)Cite this article

Abstract

IN 1949 it was demonstrated by Otto Krayer1 that the heart-rate-increasing action of adrenaline could be selectively antagonized by veratramine through a direct inhibitory action on the pacemaker of the heart. Since then it has become established that secondary amine bases of steroid nature among veratrum alkaloids all share this property in common and the term ‘anti-accelerator’ was given to this property2. More recently this property has been recognized as occurring in several types of compounds other than veratrum alkaloids3,4.

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References

  1. Krayer, O., J. Pharmacol. and Exp. Therap., 96, 422 (1949).

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  2. Krayer, O., in “Pharmacology in Medicine”, second ed., edit. by Drill, V. A., Chap. 34 (McGraw-Hill, New York, 1958).

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  3. Krayer, O., J. Pharmacol. and Exp. Therap., 100, 146 (1950).

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  4. Fuentes, J., J. Pharmacol. and Exp. Therap., 119, 427 (1957).

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  5. Hashimoto, K., Shigei, T., Imai, S., Saito, Y., Yago, N., Uei, I., and Clark, R. E., Amer. J. Physiol., 198, 965 (1960).

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  6. Smith, A. D., Ashwood-Smith, M. J., and Lowman, D., Nature, 184, 1729 (1959).

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Authors and Affiliations

  1. Iatrochemical Institute of the Pharmacological Research Foundation, and Department of Pharmacology, Faculty of Medicine, University of Tokyo, Tokyo

    SHOICHI IMAI, TATSURO SHIGEI & KOROKU HASHIMOTO

Authors
  1. SHOICHI IMAI
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  2. TATSURO SHIGEI
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  3. KOROKU HASHIMOTO
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IMAI, S., SHIGEI, T. & HASHIMOTO, K. Antiaccelerator Action of Methoxamine. Nature 189, 493–494 (1961). https://doi.org/10.1038/189493a0

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