Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Fibrinolytic Activities present in Human Blood Platelets

Abstract

BLOOD platelets have been shown to contain antiplasmin activity1–3. The experiments to be described in this communication demonstrate that blood platelets interfere in still another way in fibrinolysis. The fibrinolytic activity brought about by streptokinase comprises two steps4 : (1) activation of a proactivator which could be identical in man with plasminogen ; (2) transformation of plasminogen to plasmin by the activator, resulting from reaction (1).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Johnson, S. A., and Schneider, C. L., Science, 117, 229 (1953).

    Article  ADS  CAS  Google Scholar 

  2. Stefanini, M., and Murphy, I. S., J. Clin. Invest., 35, 355 (1956).

    Article  CAS  Google Scholar 

  3. Sherry, S., and Alkjaersig, N., Thromb. Diath. haem., 1, 264 (1957).

    Article  CAS  Google Scholar 

  4. Müllertz, S., Biochem. J., 61, 424 (1955).

    Article  Google Scholar 

  5. Astrup, T., and Müllertz, S., Arch. Biochem., 40, 346 (1952).

    Article  CAS  Google Scholar 

  6. Gross, R., and Schwick, G., Klin. Wschr., 35, 814 (1957).

    Article  CAS  Google Scholar 

  7. Niewiarowski, S., and Kowalski, E., Trans. Sixth Congress European Society of Hæmatology, Copenhagen, 560 (1957).

  8. Astrup, T., Blood, 11, 781 (1956).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HOLEMANS, R., GROSS, R. Fibrinolytic Activities present in Human Blood Platelets. Nature 189, 238–239 (1961). https://doi.org/10.1038/189238a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/189238a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing