Abstract
ALTHOUGH several of the known streptococcal enzymes or toxins have been suspected of playing a part in the pathogenesis of the heart lesions in rheumatic fever, a number of reports have suggested that streptolysin O may be of some importance in the causation of focal cardiac damage in experimental animals. Kellner et al.1 have demonstrated that the rabbit heart in vitro is extremely sensitive to this substance. Schwab et al.2, among others, showed that rabbits pre-treated with certain streptococcal factors developed a high incidence of focal cardiac lesions on subsequent injection of streptolysin O containing filtrates. These investigations were carried out with impure preparations of unknown complexity.
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References
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HALBERT, S., BIRCHER, R. & DAHLE, E. Cardiac Effects of Streptolysin O in Rabbits. Nature 189, 232–233 (1961). https://doi.org/10.1038/189232a0
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DOI: https://doi.org/10.1038/189232a0
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