Abstract
RECENT advances in the study of protein–protein interactions1, including the haptoglobin–hæmoglobin2 and protamine–fibrinogen3 complexes, have stimulated interest in serum protein abnormalities such as macroglobulin aggregation4. Although the serum proteins frequently undergo significant alterations with the onset of disease and yield characteristic patterns on electrophoretic separation, little is known about their interdependence in the healthy state. The present report describes an electrophoretic examination of interrelations between protein fractions in the course of variations within the normal human range.
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Waugh, D. F., Adv. Protein Chem., 9, 325 (1954).
Jayle, M. F., Bull. Soc. Chim. Biol. (Paris), 21, 14 (1939).
Mylon, E., Winternitz, M. C., and Sütö-Nagy, G. J., J. Biol. Chem., 143, 21 (1942).
Deutsch, H. F., and Morton, J. I., Science, 125, 600 (1957).
Brattsten, I., Ark. Kemi, 8, 347 (1956).
Wallenius, G., Trautman, R., Kunkel, H. G., and Franklin, E. C., J. Biol. Chem., 225, 253 (1957).
Schultze, H. E., Clin. Chim. Acta, 3, 24 (1958).
Tata, J. R., Nature, 183, 877 (1959).
Armstrong, S. H., Budka, M. J. E., and Morrison, K. C., J. Amer. Chem. Soc., 69, 416 (1947).
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BRACKENRIDGE, C. Interrelations of Serum Protein Fractions in Normal Humans. Nature 188, 155 (1960). https://doi.org/10.1038/188155a0
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DOI: https://doi.org/10.1038/188155a0
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