Abstract
SINCE the activity of ‘factor 3’ in liver necrosis in rats and exudative diathesis in chicks was shown to be dependent on selenium1, compounds of this element have been shown to prevent other diseases induced by tocopherol-deficient diets. Sodium selenite (0.2 p.p.m.) as well as tocopherol acetate inhibit muscular degeneration in pigs fed grain, which causes field outbreaks2. Muscular degeneration in pigs is associated with a rise in plasma glutamic-oxaloacetic transaminase, but normal ornithine-carbamyl transferase3. When the disease is manifested, high glutamic-oxaloacetic transaminase levels rapidly return to normal after subcutaneous administration of 0.02 mgm. selenium (as Na2SeO3) per kgm. body-weight daily for three days (Orstadius et al., unpublished work).
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References
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ORSTADIUS, K. Toxicity of a Single Subcutaneous Dose of Sodium Selenite in Pigs. Nature 188, 1117 (1960). https://doi.org/10.1038/1881117a0
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DOI: https://doi.org/10.1038/1881117a0
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