Abstract
CURRENT work in this laboratory shows that the exposure of driven rat ventricle strips to Locke's solutions, in which all the chloride has been substituted by nitrate, results in an increase of the total sodium in the tissue. In order to determine how this increase was partitioned between the extracellular and the intracellular compartments we attempted to measure the extracellular space by the distribution of sucrose. The results presented below show that this cannot be done in the case of nitrate, and reveal an interesting feature of the action of this anion, which may be that of increasing the permeability of cardiac tissue to a molecular species not ordinarily considered as being able to traverse the cell membrane.
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TAKETA, S., ALEXANDER, C. & FRIGEN, G. Effect of Nitrate Ion on the Distribution of Sucrose in the Rat's Ventricle. Nature 187, 419–420 (1960). https://doi.org/10.1038/187419b0
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DOI: https://doi.org/10.1038/187419b0
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