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Bradykinin-releasing Factor from Bothrops jararaca venom

Nature volume 187, pages 414–415 (1960)Cite this article

Abstract

IT was first shown by Rocha e Silva, Beraldo and Rosenfeld1 that the venom of the snake Bothrops jararaca contains a bradykinin-releasing substance. Holtz and Raudonat2 verified that the bradykinin releasing substance is precipitated with ammonium sulphate at the level of 60 per cent, is independent of the proteolytic activity on hæmoglobin and accompanies the coagulating activity. Hamberg and Rocha e Silva3 observed that the bradykinin-releasing factor is heat-resistant and that the decrease of its activity in presence of prolonged heating is parallel to that of the coagulating activity and to the fall of esterase activity on L-benzoylarginine methyl ester. Recently, Contzen, Holtz and Raudonat4 found that the bradykinin-releasing substance is dialysable and ultra-filtrable, being independent of the coagulating factor but being accompanied by the hydrolysing activity on L-benzoyl-arginine methyl ester.

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References

  1. Rocha e Silva, M., Beraldo, W. T., and Rosenfeld, G., Amer. J. Physiol., 156, 261 (1949).

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  2. Holtz, P., and Raudonat, H. W., Arch. Exp. Pathol. Pharmakol., 229, 113 (1956).

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  3. Hamberg, U., and Rocha e Silva, M., Experientia, 13, 489 (1957).

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  4. Contzen, C. H., Holtz, P., and Raudonat, H. W., Naturwiss., 46, 402 (1959).

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  5. Henriques, O. B., Lavras, A. A. C., Fichman, M., Mandelbaum, F. R., and Henriques, S. B., Biochem. J., 68, 597 (1958).

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  6. Henriques, O. B., Fichman, M., and Henriques, S. B., Biochem. J. (in the press).

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Author notes

  1. W. T. BERALDO

    Present address: Faculdade de Medicina da U.M.G., Belo Horizonte, Minas Gerais,

Authors and Affiliations

  1. Laboratory of Biochemistry, Institute Butantan, C.P. 65, São Paulo

    OLGA B. HENRIQUES & MINA FICHMAN

  2. Department of Physiology, Faculdade de Medicina da U.S.P., São Paulo

    W. T. BERALDO

Authors
  1. OLGA B. HENRIQUES
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  2. MINA FICHMAN
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  3. W. T. BERALDO
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HENRIQUES, O., FICHMAN, M. & BERALDO, W. Bradykinin-releasing Factor from Bothrops jararaca venom. Nature 187, 414–415 (1960). https://doi.org/10.1038/187414a0

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