Abstract
IN the course of studies of possible enzymically catalysed reactions of coenzyme I (diphosphopyridine nucleotide) with 5-OH-tryptamine (serotonin), tryptamine and tryptophan1, it was observed that these indoles react non-enzymically with coenzyme I. Thus, when 5-OH-tryptamine was added to a solution of coenzyme I, an intense yellow coloration appeared. Tryptamine and tryptophan also reacted in the same manner, but larger concentrations of the latter substances were required in order to give the same intensity of colour. Spectral characteristics of the coloured materials are shown in Fig. 1.
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References
Alivisatos, S. G. A., in “Mechanisms of Hypersensitivity” edit. by Shaffer, J. H., LoGrippo, G. A., and Chase, M. W., 259 (Little, Brown and Co., Boston, 1959).
Meyerhof, O., Ohlmeyer, P., and Mohle, W., Biochem. Z., 297, 113 (1938).
Colowick, S. P., Kaplan, N. O., and Ciotti, M. M., J. Biol. Chem., 191, 447 (1951).
Burton, R. M., San Pietro, A., and Kaplan, N. O., Arch. Biochem. Biophys., 70, 87 (1957).
Van Eys, J., J. Biol. Chem., 233, 1203 (1958).
Kornberg, A., and Horecker, B. L., in “Biochemical Preparations”, 3, 23, edit. by Snell, E. E. (J. Wiley and Sons, New York, 1953).
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ALIVISATOS, S., MOURKIDES, G. & JIBRIL, A. Non-Enzymic Reactions of Indoles with Coenzyme I. Nature 186, 718–719 (1960). https://doi.org/10.1038/186718a0
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DOI: https://doi.org/10.1038/186718a0
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