Abstract
IT has recently been shown that ribonucleic and deoxyribonucleic acids injected in rats and mice can markedly influence the post-irradiation survival1–3; but the exact nature of the mechanism responsible for this beneficial effect is at present unknown. An attempt has been made to give a partial answer to this problem by studying the restorative effect of a ribonucleic acid extracted from yeast, as well as the products of a progressive degradation by controlled alkaline hydrolysis of the same substance, upon rats which had received a single whole-body dose of X-rays. The selected irradiation dose corresponded approximately to the LD85(30) for the control animals the death of which was due to acute damage caused to hæmatopoietic tissues. The 30-day survival of the treated animals was taken as a criterion of effectiveness.
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MAISIN, J., DUMONT, P. & DUNJIC, A. Yeast Ribonucleic Acid and its Nucleotides as Recovery Factors in Rats receiving an Acute Whole-Body Dose of X-Rays. Nature 186, 487–488 (1960). https://doi.org/10.1038/186487a0
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DOI: https://doi.org/10.1038/186487a0
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